Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab150779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 10% DMSO, 0.1% BSA
    Note: 50mM Tris, 5mM EDTA

General Info

  • Alternative names
    • M3K7_HUMAN
    • MAP3K 7
    • Map3k7
    • MEKK7
    • Mitogen activated protein kinase kinase kinase 7
    • Mitogen-activated protein kinase kinase kinase 7
    • TAK1
    • TGF beta activated kinase 1
    • TGF-beta-activated kinase 1
    • TGF1a
    • Transforming growth factor beta activated kinase 1
    • Transforming growth factor-beta-activated kinase 1
    see all
  • Function
    Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Association with TAB1/MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.
    Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
  • Information by UniProt

References

ab150779 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thanks so much for contacting us with the customer's enquiry.

We did not previously sell this peptide, but I've had my colleagues add it to our catalog. This peptide is now available as TAK1 peptide (ab150779)-

https://www.abcam.com...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up