Overview

  • Product name

    Anti-Tal1 (phospho S122) antibody
    See all Tal1 primary antibodies
  • Description

    Rabbit polyclonal to Tal1 (phospho S122)
  • Host species

    Rabbit
  • Specificity

    ab138646 detects endogenous levels of Tal1 only when phosphorylated at S122
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized phospho-peptide derived from the internal region of Human Tal1 around the phosphorylation site of S122.

  • Positive control

    • Extracts from Jurkat cells treated with PMA.

Properties

Applications

Our Abpromise guarantee covers the use of ab138646 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

Target

  • Function

    Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
  • Tissue specificity

    Leukemic stem cell.
  • Involvement in disease

    Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Domain

    The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
  • Post-translational
    modifications

    Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.
    Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • bHLHa17 antibody
    • Class A basic helix-loop-helix protein 17 antibody
    • OTTHUMP00000009563 antibody
    • OTTHUMP00000009564 antibody
    • SCL antibody
    • STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody
    • Stem cell protein antibody
    • T cell acute lymphocytic leukemia 1 antibody
    • T cell acute lymphocytic leukemia 1 protein antibody
    • T cell acute lymphocytic leukemia 1 protein antibody
    • T cell leukemia/lymphoma 5 protein antibody
    • T-cell acute lymphocytic leukemia protein 1 antibody
    • T-cell leukemia/lymphoma protein 5 antibody
    • Tal 1 antibody
    • Tal 1 product antibody
    • TAL 1 protein antibody
    • TAL bHLH transcription factor 1 erythroid differentiation factor antibody
    • TAL-1 antibody
    • tal1 antibody
    • TAL1_HUMAN antibody
    • TCL 5 antibody
    • TCL5 antibody
    see all

Images

  • Anti-Tal1 (phospho S122) antibody (ab138646) at 1/500 dilution + Jurkat cell lysate (from cells treated with PMA at 125ng/ml for 30 minutes) at 30 µg

    Predicted band size: 34 kDa

References

ab138646 has not yet been referenced specifically in any publications.

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