Anti-Tal1 (phospho S122) antibody (ab138646)

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Western blot - Anti-Tal1 (phospho S122) antibody (ab138646)

    Key features and details

    • Rabbit polyclonal to Tal1 (phospho S122)
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-Tal1 (phospho S122) antibody
      See all Tal1 primary antibodies

    • Description

      Rabbit polyclonal to Tal1 (phospho S122)

    • Host species

      Rabbit

    • Specificity

      ab138646 detects endogenous levels of Tal1 only when phosphorylated at S122

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse

    • Immunogen

      Synthesized phospho-peptide derived from the internal region of Human Tal1 around the phosphorylation site of S122.

    • Positive control

      • Extracts from Jurkat cells treated with PMA.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab138646 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    1/500 - 1/1000. Predicted molecular weight: 34 kDa.
    Notes
    WB
    1/500 - 1/1000. Predicted molecular weight: 34 kDa.

    Target

    • Function

      Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.

    • Tissue specificity

      Leukemic stem cell.

    • Involvement in disease

      Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

    • Sequence similarities

      Contains 1 basic helix-loop-helix (bHLH) domain.

    • Domain

      The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

    • Post-translational
      modifications

      Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.
      Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    • Database links

      • Alternative names

        • bHLHa17 antibody
        • Class A basic helix-loop-helix protein 17 antibody
        • OTTHUMP00000009563 antibody
        • OTTHUMP00000009564 antibody
        • SCL antibody
        • STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody
        • Stem cell protein antibody
        • T cell acute lymphocytic leukemia 1 antibody
        • T cell acute lymphocytic leukemia 1 protein antibody
        • T cell acute lymphocytic leukemia 1 protein antibody
        • T cell leukemia/lymphoma 5 protein antibody
        • T-cell acute lymphocytic leukemia protein 1 antibody
        • T-cell leukemia/lymphoma protein 5 antibody
        • Tal 1 antibody
        • Tal 1 product antibody
        • TAL 1 protein antibody
        • TAL bHLH transcription factor 1 erythroid differentiation factor antibody
        • TAL-1 antibody
        • tal1 antibody
        • TAL1_HUMAN antibody
        • TCL 5 antibody
        • TCL5 antibody
        see all

      Images

      • Western blot - Anti-Tal1 (phospho S122) antibody (ab138646)
        Western blot - Anti-Tal1 (phospho S122) antibody (ab138646)
        Anti-Tal1 (phospho S122) antibody (ab138646) at 1/500 dilution + Jurkat cell lysate (from cells treated with PMA at 125ng/ml for 30 minutes) at 30 µg

        Predicted band size: 34 kDa

      References (1)

      Publishing research using ab138646? Please let us know so that we can cite the reference in this datasheet.

      ab138646 has been referenced in 1 publication.

      • Godavarthy PS  et al. The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis. Haematologica 105:136-147 (2020). PubMed: 31018977

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