Key features and details
- Mouse monoclonal [68E7] to Talin 2
- Reacts with: Mouse
- Isotype: IgG2b
Product nameAnti-Talin 2 antibody [68E7]
See all Talin 2 primary antibodies
DescriptionMouse monoclonal [68E7] to Talin 2
Species reactivityReacts with: Mouse
Recombinant fragment, corresponding to amino acids 489-911 of Mouse Talin 2.
General notesGrowth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37°C + 5%CO2
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A purified
FunctionAs a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.
Sequence similaritiesContains 1 FERM domain.
Contains 1 I/LWEQ domain.
Cellular localizationCell junction > focal adhesion. Cell junction > synapse. Cell membrane. Cytoplasm > cytoskeleton. Focal adhesion plaques and synapses.
- Information by UniProt
- DKFZp451B1011 antibody
- DKFZp686I0976 antibody
- DKFZp686K0979 antibody
ab105458 has been referenced in 6 publications.
- Böttcher RT et al. Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. J Cell Biol 216:3785-3798 (2017). PubMed: 28912124
- Bouchet BP et al. Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions. Elife 5:N/A (2016). WB . PubMed: 27410476
- Fang KP et al. Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell. BMC Cancer 16:45 (2016). PubMed: 26822056
- Theodosiou M et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife 5:e10130 (2016). WB ; Mouse . PubMed: 26821125
- Austen K et al. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol 17:1597-606 (2015). PubMed: 26523364
- Debrand E et al. Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. FEBS J 276:1610-28 (2009). PubMed: 19220457