Overview

  • Product name

    Anti-Talin 2 antibody [68E7]
    See all Talin 2 primary antibodies
  • Description

    Mouse monoclonal [68E7] to Talin 2
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Fr, ICC/IF, IP, WB, ELISAmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Recombinant fragment, corresponding to amino acids 489-911 of Mouse Talin 2.

  • Positive control

    • Fibroblasts
  • General notes

    Growth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37°C + 5%CO2

Properties

Applications

Our Abpromise guarantee covers the use of ab105458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
ICC/IF 1/100 - 1/1000.
IP 1/100 - 1/1000.
WB 1/100 - 1/1000. Predicted molecular weight: 272 kDa.
ELISA 1/100 - 1/1000.

Target

  • Function

    As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.
  • Sequence similarities

    Contains 1 FERM domain.
    Contains 1 I/LWEQ domain.
  • Cellular localization

    Cell junction > focal adhesion. Cell junction > synapse. Cell membrane. Cytoplasm > cytoskeleton. Focal adhesion plaques and synapses.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp451B1011 antibody
    • DKFZp686I0976 antibody
    • DKFZp686K0979 antibody
    • ILWEQ antibody
    • KIAA0320 antibody
    • Talin-2 antibody
    • talin2 antibody
    • TLN 2 antibody
    • TLN2 antibody
    • TLN2_HUMAN antibody
    see all

References

This product has been referenced in:

  • Böttcher RT  et al. Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. J Cell Biol 216:3785-3798 (2017). Read more (PubMed: 28912124) »
  • Bouchet BP  et al. Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions. Elife 5:N/A (2016). WB . Read more (PubMed: 27410476) »
See all 6 Publications for this product

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