Overview

  • Product name
    TAME hydrochloride
  • Description
    Competitive ubiquitin ligase APC/C inhibitor.
  • Biological description
    Competitive ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) inhibitor. Promotes Cdc20 autoubiquitination by ejecting Cdc20 from the APC. Induces mitotic arrest.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Zeng X & King RW An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol 8:383-92 (2012). Read more (PubMed: 22366722) »
  • Zeng X  et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18:382-95 (2010). Read more (PubMed: 20951947) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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