Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist (ab146136)

Overview

  • Product name

    Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist
  • Description

    Potent, selective 5-HT1A partial agonist
  • Biological description

    Potent, selective 5-HT1A partial agonist (Ki = 27 nM). Decreases the firing rate of 5-HT neurons of the dorsal raphe. Shows anxiolytic and antidepressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    99095-10-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
  • Molecular weight

    419.95
  • Molecular formula

    C21H29N5O2.HCl
  • PubChem identifier

    13422623
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=NC=CC=N5.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Miyawaki K  et al. Disruption of running activity rhythm following restricted feeding in female mice: Preventive effects of antidepressants. J Pharmacol Sci 127:382-90 (2015). Read more (PubMed: 25837938) »
  • Murata Y  et al. Chronic treatment with tandospirone, a serotonin 1A receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior. J Affect Disord 180:1-9 (2015). Read more (PubMed: 25879718) »
  • Godbout R  et al. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology 30:679-90 (1991). Read more (PubMed: 1681446) »

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