Overview

  • Product name

    Tanespimycin (17-AAG), HSP90 inhibitor
  • Description

    Potent, selective HSP90 inhibitor
  • Alternative names

    • 17-AAG
    • BMS 722782
    • CP 127374
    • KOS 953
    • NSC 330507
    see all
  • Biological description

    Potent, selective HSP90 inhibitor (IC50 = 5 nM). Anticancer activity, including cytostatic, proapoptotic and antiangiogenic properties in vitro and in vivo.

  • Purity

    > 98%
  • CAS Number

    75747-14-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wenyong T  et al. An experimental study on the antitumor effect of 131I-17-AAG in vitro and in vivo. Ann Nucl Med 23:113-22 (2009). Read more (PubMed: 19225933) »
  • Konstantinopoulos PA & Papavassiliou AG 17-AAG: mechanisms of antitumour activity. Expert Opin Investig Drugs 14:1471-4 (2005). Read more (PubMed: 16307487) »
  • Le Brazidec JY  et al. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90. J Med Chem 47:3865-73 (2004). Read more (PubMed: 15239664) »
  • Kamal A  et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425:407-10 (2003). Read more (PubMed: 14508491) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141433.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up