Tangeretin (Tangeritin), Antiproliferative and antioxidant agent (ab143153)

Overview

  • Product name

    Tangeretin (Tangeritin), Antiproliferative and antioxidant agent
  • Description

    Antiproliferative and antioxidant agent
  • Biological description

    Antiproliferative and antioxidant agent. Blocks cell cycle progression at G1. Shows anti-inflammatory, osteoprotective and neuroprotective effects. Blood-brain barrier permeable. Active in vivo.
  • Purity

    > 97%
  • CAS Number

    481-53-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)chromen-4-one
  • Molecular weight

    372.37
  • Molecular formula

    C20H20O7
  • PubChem identifier

    68077
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C(=C2C(=C1OC)OC(=CC2=O)C3=CC=C(C=C3)OC)OC)OC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tominari T  et al. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. J Pharmacol Sci 119:390-4 (2012). Read more (PubMed: 22850615) »
  • Morley KL  et al. Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett 251:168-78 (2007). Read more (PubMed: 17197076) »
  • Datla KP  et al. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport 12:3871-5 (2001). Read more (PubMed: 11726811) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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