Overview

  • Product name

  • Description

    Rabbit polyclonal to TANK/TRAF2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Recombinant fragment within Human TANK/TRAF2 (internal sequence). The exact sequence is proprietary.
    Database link: Q92844

  • Positive control

    • WB: Partial TANK/TRAF2 fragment-transfected HEK-293T whole cell extract; Human colon extract.
  • General notes

     This product was previously labelled as TANK

     

Properties

Applications

Our Abpromise guarantee covers the use of ab227716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/20000. Predicted molecular weight: 48 kDa.

Target

  • Function

    Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Contains 1 C2H2-type zinc finger.
  • Post-translational
    modifications

    Phosphorylated by IKBKE.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • I TRAF antibody
    • I-TRAF antibody
    • ITRAF antibody
    • Tank antibody
    • TANK_HUMAN antibody
    • TRAF family member associated NF KAPPA B activator antibody
    • TRAF family member associated NFKB activator antibody
    • TRAF family member-associated NF-kappa-B activator antibody
    • TRAF interacting protein antibody
    • TRAF interacting protein TANK isoform a antibody
    • TRAF interacting protein TANK isoform b antibody
    • TRAF-interacting protein antibody
    • TRAF2 antibody
    see all

Images

  • All lanes : Anti-TANK/TRAF2 antibody (ab227716) at 1/20000 dilution

    Lane 1 : Non-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract
    Lane 2 : Partial TANK/TRAF2 fragment-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 48 kDa



    10% SDS-PAGE gel.

  • Anti-TANK/TRAF2 antibody (ab227716) at 1/1000 dilution + Human colon extract at 30 µg

    Predicted band size: 48 kDa



    10% SDS-PAGE gel.

References

ab227716 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227716.
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