• Product name
  • Description
    Goat polyclonal to Tankyrase 2
  • Host species
  • Specificity
    No crossreactivity expected with Tankyrase 1.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog
  • Immunogen

    Fusion protein containing 73 amino acids from the 800-900 amino acid region of Human Tankyrase 2 (NP_079511.1).

  • Positive control
    • HEK293 overexpressing Tankyrase 2



Our Abpromise guarantee covers the use of ab92329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 127 kDa (predicted molecular weight: 127 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
    • Tissue specificity
      Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
    • Sequence similarities
      Contains 15 ANK repeats.
      Contains 1 PARP catalytic domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • Post-translational
      Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
      ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
      The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
    • Cellular localization
      Cytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
    • Information by UniProt
    • Database links
    • Alternative names
      • ADP-ribosyltransferase diphtheria toxin-like 6 antibody
      • ARTD6 antibody
      • PARP 5b antibody
      • PARP 5c antibody
      • PARP-5b antibody
      • PARP-5c antibody
      • PARP5B antibody
      • PARP5C antibody
      • pART6 antibody
      • Poly [ADP ribose] polymerase 5B antibody
      • Poly [ADP-ribose] polymerase 5B antibody
      • TANK2 antibody
      • Tankyrase 2 antibody
      • Tankyrase II antibody
      • Tankyrase like protein antibody
      • Tankyrase related protein antibody
      • Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody
      • Tankyrase-2 antibody
      • Tankyrase-like protein antibody
      • Tankyrase-related protein antibody
      • TNKL antibody
      • TNKS 2 antibody
      • TNKS-2 antibody
      • TNKS2 antibody
      • TNKS2_HUMAN antibody
      • TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody
      • TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
      see all


    • All lanes : Anti-Tankyrase 2 antibody (ab92329) at 0.5 µg/ml

      Lane 1 : Mock transfection
      Lane 2 : HEK293 overexpressing Tankyrase 1

      Lane 3 : HEK293 overexpressing Tankyrase 2

      Developed using the ECL technique.

      Predicted band size: 127 kDa
      Observed band size: 127 kDa

      Primary incubation was overnight at 4°C.


    This product has been referenced in:
    • Kuusela S  et al. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell Death Dis 7:e2302 (2016). IHC-Fr ; Mouse . Read more (PubMed: 27441654) »

    See 1 Publication for this product

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