Tanzisertib hydrochloride (CC-930), JNK isoforms inhibitor (ab229167)

Overview

  • Product name

    Tanzisertib hydrochloride (CC-930), JNK isoforms inhibitor
  • Description

    Selective and potent ATP-competitive inhibitor of all JNK isoforms
  • Alternative names

    • CC-930
    • JNKI-1
    • NK-930
  • Biological description

    Selective and potent ATP-competitive inhibitor of all JNK isoforms (IC50 values are 61 nM (JNK1), 5 nM (JNK2) and 5 nM (JNK3)). Selective against ERK1 (IC50 = 480 nM) and p38a (IC50 = 3.4 μM). Inhibits EGFR as only non-MAP kinase (≥ 50% by 3 μM). Displays an IC50 >10 μM against a panel of 75 receptors, ion channels and neurotransmitter transporters. Inhibits phosphorylation of c-Jun in cell-based assays. Inhibits TNFα production in LPS-induced rat model.

  • Purity

    > 99%
  • CAS Number

    899805-25-5

Properties

  • Chemical name

    trans-4-[[9-[(3S)-Tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]cyclohexanol hydrochloride

  • Molecular weight

    484.90
  • Molecular formula

    C21H23F3N6O2.HCl
  • PubChem identifier

    131709237
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM, in ethanol to 100 mM and in water to 5mM (with warming)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1COC[C@H]1N2C3=NC(=NC=C3N=C2NC4=C(C=C(C=C4F)F)F)NC5CCC(CC5)O.Cl
  • Source

    Synthetic

References

ab229167 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229167.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up