Overview

  • Product name

  • Description

    Rabbit polyclonal to TAOK2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human TAOK2 aa 719-880.
    Database link: Q9UL54

  • Positive control

    • IHC-P: Human liver cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK. Phosphorylates itself, MBP, activated MAPK8 and tubulins. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization (By similarity). Both isoforms are involved in MAPK14 phosphorylation.
  • Tissue specificity

    Ubiquitously expressed, with a higher level of expression in testis and brain.
  • Sequence similarities

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Isoforms 1 and 2 are autophosphorylated.
    C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.
    isoform 2 is phosphorylated at 'Ser-1031' by MAPK14. This phosphorylation is required PCDH8 for endocytosis.
  • Cellular localization

    Cytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus and Cell projection > dendrite. In dendrites, colocalizes with PCDH8.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1110033K02Rik antibody
    • B230344N16 antibody
    • hKFC C antibody
    • hKFC-C antibody
    • KIAA0881 antibody
    • Kinase from chicken homolog C antibody
    • MAP3K17 antibody
    • mKIAA0881 antibody
    • Prostate derived STE20 like kinase 1 antibody
    • Prostate derived STE20 like kinase PSK antibody
    • Prostate derived sterile 20 like kinase 1 antibody
    • Prostate-derived STE20-like kinase 1 antibody
    • PSK 1 antibody
    • PSK antibody
    • PSK-1 antibody
    • PSK1 antibody
    • PSK1 beta antibody
    • Serine/threonine protein kinase TAO2 antibody
    • Serine/threonine-protein kinase TAO2 antibody
    • TAO 1 antibody
    • TAO 2 antibody
    • TAO kinase 2 antibody
    • TAO1 antibody
    • TAO2 antibody
    • TAOK 2 antibody
    • Taok2 antibody
    • TAOK2_HUMAN antibody
    • Thousand and one amino acid protein 2 antibody
    • Thousand and one amino acid protein kinase antibody
    • UNQ2971/PRO7431 antibody
    see all

Images

  • Paraffin-embedded human liver cancer tissue stained for TAOK2 using ab238854 at 1/100 dilution in immunohistochemical analysis.

References

ab238854 has not yet been referenced specifically in any publications.

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