TAPI-0 (TNF-alpha processing inhibitor-0), Matrix metalloprotease (MMP) and TACE inhibitor (ab141497)

Overview

  • Product name

    TAPI-0 (TNF-alpha processing inhibitor-0), Matrix metalloprotease (MMP) and TACE inhibitor
  • Description

    TNF-α processing, matrix metalloprotease and TACE inhibitor
  • Alternative names

    • TNFa processing inhibitor0
  • Biological description

    Inhibits TNF-α processing. Also a general matrix metalloprotease and TACE inhibitor.
  • Purity

    > 95%
  • CAS Number

    143457-40-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • von Maltzan K  et al. Investigation of the role of TNF-a converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-a production by acute ethanol exposure. PLoS One 7:e29890 (2012). Read more (PubMed: 22319556) »
  • Balakrishnan A  et al. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem 281:16691-9 (2006). Read more (PubMed: 16565079) »
  • Crowe PD  et al. A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes. J Exp Med 181:1205-10 (1995). Read more (PubMed: 7869036) »

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