TAPI-1, TNF-alpha processing inhibitor (ab142218)

Overview

  • Product name

    TAPI-1, TNF-alpha processing inhibitor
  • Description

    TNF-α processing inhibitor
  • Alternative names

    • TNF-alpha protease inhibitor I
  • Biological description

    Stable, selective inhibitor of TNF-α processing (IC50 = ~100 nM).  Inhibits TACE (P< 0.01) and other metalloproteases in vivo. Blocks release of TNF-α (IC50 = 50-100 µM), APP (IC50 = 1-8 µM), ACE (IC50 = 10 µM), IL6R (IC50 = 5-10 µM), TNFRI (IC50 = 5-10 µM), TNFRII (IC50 = 25-50 µM), and ObRa (leptin receptor), but not CSF-1 in vivo. Structural analog of TAPI-0.

  • Purity

    > 95%
  • CAS Number

    171235-71-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide

  • Molecular weight

    499.60
  • Molecular formula

    C26H37N5O5
  • PubChem identifier

    9827273
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 10 mM

  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILES

    CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN
  • Source

    Synthetic

References

ab142218 has not yet been referenced specifically in any publications.

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