Overview

  • Product name

    TAPI-2, MMP and ADAM inhibitor
  • Description

    Broad spectrum MMP and ADAM inhibitor
  • Alternative names

    • TNF Protease Inhibitor 2
    • Tumor necrosis factor alpha protease inhibitor 2
  • Biological description

    Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC50 = 10 µM). Inhibits TNF-α release.

  • Purity

    > 95%
  • CAS Number

    187034-31-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide

  • Molecular weight

    415.28
  • Molecular formula

    C19H37N5O5
  • PubChem identifier

    10093303
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in water to 50 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C
  • Source

    Synthetic

References

ab142219 has not yet been referenced specifically in any publications.

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