Key features and details
- Mouse monoclonal [B11E8] to Tau 13
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-Tau 13 antibody [B11E8]
DescriptionMouse monoclonal [B11E8] to Tau 13
SpecificityThe antibody recognizes 45-60 kDa human Tau-13. Reactivity to other species has not been tested.
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Tau 13 (N terminal).
Database link: P10636
Abcam is committed to meeting high quality standards of ethical manufacturing and has decided to discontinue this product on 31st March 2021 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.
The antibody recognizes 45-60 kDa isoform of human Tau-13.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, Ascites, 50% Glycerol (glycerin, glycerine), 1% BSA
Concentration information loading...
Primary antibody notesThe antibody recognizes 45-60 kDa isoform of human Tau-13.
RelevanceTau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF)and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK 3 beta, PKA, Cdk 5, and casein kinase II can phosphorylate tau.
Cellular localizationCytoplasmic and Plasma membrane
- FTDP17 antibody
- Microtubule associated protein tau antibody
- Paired helical filament tau antibody
ab19030 has been referenced in 6 publications.
- Cassar M et al. Disease-Associated Mutant Tau Prevents Circadian Changes in the Cytoskeleton of Central Pacemaker Neurons. Front Neurosci 14:232 (2020). PubMed: 32292325
- Kim DK et al. Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics. Mol Neurodegener 13:2 (2018). WB . PubMed: 29338754
- Vega IE et al. Ezrin Expression is Increased During Disease Progression in a Tauopathy Mouse Model and Alzheimer's Disease. Curr Alzheimer Res 15:1086-1095 (2018). PubMed: 30101710
- Haj-Yahya M & Lashuel HA Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. J Am Chem Soc 140:6611-6621 (2018). PubMed: 29684271
- Lathuilière A et al. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Sci Rep 7:13556 (2017). ELISA ; Human . PubMed: 29051562
- Ait-Bouziad N et al. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nat Commun 8:1678 (2017). PubMed: 29162800