Taxifolin (Dihydroquercetin), chemopreventive agent (ab143154)

Overview

  • Product name

    Taxifolin (Dihydroquercetin), chemopreventive agent
  • Description

    Flavanonol. Chemopreventive agent.
  • Biological description

    Flavanonol. Chemopreventive agent. Inhibits EGFR and PI3K. Suppresses Akt. Quercetin (ab120247) derivative. Enhances microtubule dynamics disruption and potentiates the antiproliferative effects of andrographolide (ab120636). Shows chemopreventive effects in vivo. Orally active.
  • Purity

    > 96%
  • CAS Number

    480-18-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
  • Molecular weight

    304.25
  • Molecular formula

    C15H12O7
  • PubChem identifier

    439533
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM (with warming) and in ethanol to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Pantouris G & Mowat CG Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase. Biochem Biophys Res Commun 443:28-31 (2014). Read more (PubMed: 24269239) »
  • Zhang ZR  et al. Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation. PLoS One 8:e54577 (2013). Read more (PubMed: 23382917) »
  • Oi N  et al. Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev Res (Phila) 5:1103-14 (2012). Read more (PubMed: 22805054) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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