Anti-TBCE antibody (ab224664)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-TBCE antibody
See all TBCE primary antibodies -
Description
Rabbit polyclonal to TBCE -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human TBCE aa 328-527.
Database link: Q15813 -
Positive control
- IHC-P: Human prostate cancer tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab224664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/20 - 1/200. |
Target
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Function
Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. -
Involvement in disease
Defects in TBCE are a cause of hypoparathyroidism-retardation-dysmorphism syndrome (HRD) [MIM:241410]; also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations.
Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1) [MIM:244460]. KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. -
Sequence similarities
Belongs to the TBCE family.
Contains 1 CAP-Gly domain.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain. -
Cellular localization
Cytoplasm. Cytoplasm > cytoskeleton. - Information by UniProt
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Database links
- Entrez Gene: 6905 Human
- Omim: 604934 Human
- SwissProt: Q15813 Human
- Unigene: 727621 Human
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Alternative names
- HRD antibody
- KCS antibody
- KCS1 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBCE antibody (ab224664)Paraffin-embedded human prostate cancer tissue stained for TBCE using ab224664 at 1/100 dilution in immunohistochemical analysis.
Datasheets and documents
References
ab224664 has not yet been referenced specifically in any publications.
