Overview

  • Product name

    Anti-TBRG1 antibody
  • Description

    Rabbit polyclonal to TBRG1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human TBRG1 aa 10-60 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    S PRAPLQSSKA RMKKLPKKSQ NEKYRLKYLR LRKAAKATVF ENAAICDEIA


    Database link: Q3YBR2-1

  • Positive control

    • Rat kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab203276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 45 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at 1/50 - 1/200 with fluorescent detection methods.

Target

  • Relevance

    Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. Similarity: Belongs to the TBRG1 family. Contains 1 FYR C-terminal domain. Contains 1 FYR N-terminal domain. PTM: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • NIAM antibody
    • Nuclear interactor of ARF and Mdm2 antibody
    • TB 5 antibody
    • tbrg1 antibody
    • TBRG1 regulator 1 antibody
    • TBRG1_HUMAN antibody
    • Transforming growth factor beta regulator 1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin embedded rat pancreas tissue labeling TBRG1 using ab203276 at 1/200, followed by secondary detection and DAB staining.

References

ab203276 has not yet been referenced specifically in any publications.

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