Anti-TC-2 antibody (ab189871)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-TC-2 antibody
See all TC-2 primary antibodies -
Description
Rabbit polyclonal to TC-2 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human TC-2 aa 19-250.
Sequence:EMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTK EDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEF VRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQ KRVHDSVVDKLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQR ITMAIRTVREEILKAQTPEGHFGNVYSTPLAL
Database link: P20062 -
Positive control
- SW480, MCF7, A549, U-251MG cell line extracts; Mouse kidney and lung tissue extracts
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General notes
Previously labelled as TCN2.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab189871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/2000. Predicted molecular weight: 48 kDa. | |
| IHC-P | 1/50 - 1/200. |
Target
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Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. -
Involvement in disease
Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia. -
Sequence similarities
Belongs to the eukaryotic cobalamin transport proteins family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 6948 Human
- Omim: 275350 Human
- SwissProt: P20062 Human
- Unigene: 417948 Human
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Alternative names
- D22S676 antibody
- D22S750 antibody
- II antibody
see all
Images
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Western blot - Anti-TC-2 antibody (ab189871)All lanes : Anti-TC-2 antibody (ab189871) at 1/500 dilution
Lane 1 : SW620 cell extracts
Lane 2 : MCF7 cell extracts
Lane 3 : A549 cell extracts
Lane 4 : U-25MG cell extracts
Lane 5 : Mouse kidney tissue extracts
Lane 6 : Mouse lung tissue extracts
Predicted band size: 48 kDa
Datasheets and documents
References
ab189871 has not yet been referenced specifically in any publications.
