Overview

  • Product name

    TC-2403 oxalate, alpha4beta2 nAChR selective agonist
  • Description

    Potent α4β2 nAChR selective agonist
  • Alternative names

    • RJR 2403
  • Biological description

    High affinity α4β2 nAChR selective agonist (Ki = 26 nM). Selective for CNS nAChR over muscle, ganglionic or enteric ACh receptors (EC50 = 732 nM in rat thalamic synaptosomes).
  • Purity

    > 99%
  • CAS Number

    252870-46-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Taslim N  et al. Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) a(4)ß(2)- and a(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Behav Brain Res 217:282-92 (2011). Read more (PubMed: 20974182) »
  • Bodnar AL  et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem 48:905-8 (2005). Read more (PubMed: 15715459) »
  • Papke RL Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). J Pharmacol Exp Ther 301:765-73 (2002). Read more (PubMed: 11961083) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120557.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up