Key features and details
- Potent α4β2 nAChR selective agonist
- CAS Number: 252870-46-5
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameTC-2403 oxalate, alpha4beta2 nAChR selective agonist
DescriptionPotent α4β2 nAChR selective agonist
- RJR 2403
High affinity α4β2 nAChR selective agonist (Ki = 26 nM). Selective for CNS nAChR over muscle, ganglionic or enteric ACh receptors (EC50 = 732 nM in rat thalamic synaptosomes).
Chemical name(E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120557 has been referenced in 1 publication.
- Grandi A et al. a7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. Front Pharmacol 8:809 (2017). PubMed: 29167641