Anti-TC10 antibody (ab168645)

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Key features and details

  • Mouse polyclonal to TC10
  • Suitable for: WB, ICC/IF
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-TC10 antibody
    See all TC10 primary antibodies

  • Description

    Mouse polyclonal to TC10

  • Host species

    Mouse

  • Tested applications

    Suitable for: WB, ICC/IFmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat

  • Immunogen

    Full length protein corresponding to amino acids 1-205 of Human TC10 (NP_036381.2).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • TC10 transfected 293T cell lysate. HeLa cells.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Applications

Our Abpromise guarantee covers the use of ab168645 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function

    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

  • Sequence similarities

    Belongs to the small GTPase superfamily. Rho family.

  • Post-translational
    modifications

    May be post-translationally modified by both palmitoylation and polyisoprenylation.

  • Cellular localization

    Cytoplasm. Cell membrane.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • ARHQ antibody
    • Ras homolog gene family member Q antibody
    • RAS like family 7 member A antibody
    • Ras like protein family member 7A antibody
    • Ras like protein TC10 antibody
    • Ras related GTP binding protein TC10 antibody
    • Ras-like protein family member 7A antibody
    • Ras-like protein TC10 antibody
    • RASL7A antibody
    • Rho related GTP binding protein RhoQ antibody
    • Rho-related GTP-binding protein RhoQ antibody
    • Rhoq antibody
    • RHOQ_HUMAN antibody
    • TC10A antibody
    see all

Images

  • Western blot - Anti-TC10 antibody (ab168645)
    Western blot - Anti-TC10 antibody (ab168645)
    All lanes : Anti-TC10 antibody (ab168645) at 1 µg/ml

    Lane 1 : TC10 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate


    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP
    at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 23 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-TC10 antibody (ab168645)
    Immunocytochemistry/ Immunofluorescence - Anti-TC10 antibody (ab168645)
    Immunofluorescence analysis of HeLa cells, labeling TC10 with ab168645 at 10 µg/ml.

References (1)

Publishing research using ab168645? Please let us know so that we can cite the reference in this datasheet.

ab168645 has been referenced in 1 publication.

  • Mayer S  et al. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci U S A 110:20795-800 (2013). PubMed: 24297911

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