Key features and details
- Mouse monoclonal [EM-50] to TC21
- Suitable for: ICC/IF, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-TC21 antibody [EM-50]
See all TC21 primary antibodies
DescriptionMouse monoclonal [EM-50] to TC21
SpecificityThis antibody does not react with R-Ras1, H-Ras, K-Ras and N-Ras.
Tested applicationsSuitable for: ICC/IF, Flow Cytmore details
Species reactivityReacts with: Human
The details of the immunogen for this antibody are not available.
- ICC/IF: TC21 transfected COS cells. Flow Cytometry: TC21-GFP transfected HEK-293 cells.
Protein previously labeled as RRAS2.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. Do Not Freeze.
Storage bufferpH: 7.40
Preservative: 0.0975% Sodium azide
Concentration information loading...
PurityProtein A purified
Purification notesPurity >95% by SDS-PAGE.
Our Abpromise guarantee covers the use of ab234145 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.|
FunctionIt is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
Tissue specificityUbiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
Involvement in diseaseOvarian cancer
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family.
modificationsMay be post-translationally modified by both palmitoylation and polyisoprenylation.
Cellular localizationCell membrane. Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
- Information by UniProt
- C86394 antibody
- Oncogene RRAS2 antibody
- Oncogene TC21 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab234145 has not yet been referenced specifically in any publications.