Anti-WSX-1 antibody (ab217627)
Key features and details
- Rabbit polyclonal to WSX-1
- Suitable for: IHC-P, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-WSX-1 antibody
See all WSX-1 primary antibodies -
Description
Rabbit polyclonal to WSX-1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, Flow Cytmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide within Human WSX-1 aa 1-100 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q6UWB1 -
Positive control
- Mouse lymphoma tissue; Mouse splenocytes.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X
Aqueous buffered solution -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab217627 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/100 - 1/500.
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Flow Cyt |
1/100.
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Notes |
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IHC-P
1/100 - 1/500. |
Flow Cyt
1/100. |
Target
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Function
Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. -
Tissue specificity
Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 3 fibronectin type-III domains. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 9466 Human
- Entrez Gene: 50931 Mouse
- Entrez Gene: 288905 Rat
- Omim: 605350 Human
- SwissProt: Q6UWB1 Human
- SwissProt: O70394 Mouse
- Unigene: 132781 Human
- Unigene: 38386 Mouse
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Alternative names
- Class I cytokine receptor antibody
- CRL1 antibody
- Cytokine receptor-like 1 antibody
see all
Images
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Immunohistochemical analysis of Formalin fixed, paraffin embedded Mouse lymphoma tissue labeling WSX-1 with ab217627 at 1/200 followed by conjugation to the secondary antibody and DAB staining.
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Flow cytometric analysis of Mouse splenocytes labeling WSX-1 with ab217627 at 1/100 dilution followed by a FITC conjugated secondary antibody (green) compared to control cells (blue).
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab217627 has not yet been referenced specifically in any publications.