Overview

  • Product name

  • Description

    Rabbit polyclonal to TCF7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human TCF7 aa 142-384. The exact sequence is proprietary.
    Database link: P36402

  • Positive control

    • HepG2 and Jurkat cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab183862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 42 kDa.

Target

  • Function

    Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
  • Tissue specificity

    Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
  • Sequence similarities

    Belongs to the TCF/LEF family.
    Contains 1 HMG box DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ36364 antibody
    • MGC47735 antibody
    • OTTHUMP00000159391 antibody
    • T cell factor 1 antibody
    • T cell specific transcription factor 1 antibody
    • T-cell factor 1 antibody
    • T-cell-specific transcription factor 1 antibody
    • TCF-1 antibody
    • TCF-7 antibody
    • TCF1 antibody
    • Tcf7 antibody
    • TCF7 transcription factor 7 antibody
    • TCF7_HUMAN antibody
    • Transcription factor 7 (T cell specific HMG box) antibody
    • Transcription factor 7 antibody
    • Transcription factor-7, T-cell specific antibody
    • Transcription factor-7, T-cell specific, 1 antibody
    see all

Images

  • Anti-TCF7 antibody (ab183862) at 1/1000 dilution + HepG2 whole cell lysate/extract at 30 µg

    Predicted band size: 42 kDa

  • Anti-TCF7 antibody (ab183862) at 1/1000 dilution + Jurkat whole cell lysate/extract at 30 µg

    Predicted band size: 42 kDa

References

ab183862 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab183862.
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