Overview

  • Product name

  • Description

    Rabbit polyclonal to TCIRG1
  • Host species

    Rabbit
  • Specificity

    At least two alternatively spliced isoforms are known to exist; ab139812 will only detect the larger isoform.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 19 amino acid synthetic peptide near the amino terminus of Human TCIRG1 (NP_006010).

  • Positive control

    • EL4 cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab139812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 93 kDa.

Target

  • Function

    Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
  • Tissue specificity

    Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.
  • Involvement in disease

    Defects in TCIRG1 are the cause of osteopetrosis autosomal recessive type 1 (OPTB1) [MIM:259700]; also called autosomal recessive Albers-Schonberg disease or infantile malignant osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. The features of OPTB1 are macrocephaly, progressive deafness and blindness, hepatosplenomegaly, and severe anemia beginning in early infancy or in fetal life. Deafness and blindness are generally thought to represent effects of pressure on nerves.
  • Sequence similarities

    Belongs to the V-ATPase 116 kDa subunit family.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • a3 antibody
    • Atp 6i antibody
    • Atp6i antibody
    • ATP6N1C antibody
    • ATP6V0A3 antibody
    • ATPase H+ transporting 116kD antibody
    • OC 116 antibody
    • OC 116 kDa antibody
    • OC 116kDa antibody
    • OC-116 kDa antibody
    • OC116 antibody
    • OPTB 1 antibody
    • OPTB1 antibody
    • Osteoclastic proton pump 116 kDa subunit antibody
    • Specific 116 kDa vacuolar proton pump subunit antibody
    • Stv 1 antibody
    • Stv1 antibody
    • T cell immune regulator 1 antibody
    • T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A antibody
    • T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A3 antibody
    • T cell immune response cDNA 7 antibody
    • T cell immune response cDNA7 protein antibody
    • T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a antibody
    • T-cell immune regulator 1 antibody
    • T-cell immune response cDNA7 protein antibody
    • TCIRG 1 antibody
    • TCIRG1 antibody
    • TIRC 7 antibody
    • TIRC7 antibody
    • V ATPase 116 kDa antibody
    • V ATPase 116 kDa isoform a3 antibody
    • V type proton ATPase 116 kDa subunit a antibody
    • V-ATPase 116 kDa isoform a3 antibody
    • V-type proton ATPase 116 kDa subunit a isoform 3 antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit A antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 antibody
    • Vph 1 antibody
    • Vph1 antibody
    • VPP3_HUMAN antibody
    see all

Images

  • All lanes : Anti-TCIRG1 antibody (ab139812) at 0.5 µg/ml

    Lane 1 : EL4 cell lysate
    Lane 2 : EL4 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 93 kDa

References

This product has been referenced in:

See 1 Publication for this product

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