Overview

  • Product name
  • Description
    Chicken polyclonal to Tcl1
  • Host species
    Chicken
  • Specificity
    Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human): Tcl1

  • Positive control
    • E coli derived fusion protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab37465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/2000. Predicted molecular weight: 13 kDa.
    We recommend using about 2.5 ug of positive control protein in the colorimetric method, and about 10x less for ECL detection.



    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
    • Tissue specificity
      Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
    • Involvement in disease
      Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
    • Sequence similarities
      Belongs to the TCL1 family.
    • Cellular localization
      Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
    • Information by UniProt
    • Database links
    • Alternative names
      • Anti TCL1A antibody
      • Lymphoma/leukemia, T-cell antibody
      • Oncogene TCL-1 antibody
      • Oncogene TCL1 antibody
      • P14 TCL1 antibody
      • P14 TCL1 protein antibody
      • Protein p14 TCL1 antibody
      • T cell leukemia 1 antibody
      • T cell lymphoma 1 antibody
      • T cell lymphoma 1A antibody
      • T-cell leukemia/lymphoma 1A antibody
      • T-cell leukemia/lymphoma protein 1A antibody
      • TCL 1 protein antibody
      • TCL1 antibody
      • TCL1 oncogene antibody
      • TCL1 PEN antibody
      • Tcl1a antibody
      • TCL1A antibody antibody
      • TCL1A_HUMAN antibody
      see all

    Images

    • Anti-Tcl1 antibody (ab37465) at 1/2000 dilution + E coli-derived fusion protein

      Secondary
      Goat anti IgY HRP at 1/1000 dilution

      Predicted band size: 13 kDa
      Observed band size: 62 kDa
      why is the actual band size different from the predicted?



      A fusion protien has been used in this western blot, which accounts for the difference in molecular weights, compared to the native protien.

    References

    ab37465 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab37465.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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