Overview

  • Product name

    Anti-TCR alpha + TCR beta antibody [R73] (FITC)
    See all TCR alpha + TCR beta primary antibodies
  • Description

    Mouse monoclonal [R73] to TCR alpha + TCR beta (FITC)
  • Host species

    Mouse
  • Conjugation

    FITC. Ex: 493nm, Em: 528nm
  • Specificity

    ab176542 recognizes TCR alpha/beta, the dominant subtype of T cell receptor expressed in peripheral blood.
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Non human primates
  • Immunogen

    Tissue, cells or virus corresponding to Rat TCR alpha + TCR beta. Rat T blasts and erythrocytes.
    Database link: 24820

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C. Store In the Dark.
  • Storage buffer

    pH: 7.40
    Preservative: 0.098% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Size exclusion
  • Purification notes

    This conjugate is made from a highly purified antibody (>95% by SDS-PAGE); free of unconjugated FITC.
  • Clonality

    Monoclonal
  • Clone number

    R73
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab176542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

Target

  • Relevance

    The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.
  • Cellular localization

    Type I membrane protein.
  • Database links

  • Alternative names

    • FLJ22602 antibody
    • MGC117436 antibody
    • MGC22624 antibody
    • MGC23964 antibody
    • MGC71411 antibody
    • T cell antigen receptor alpha polypeptide antibody
    • T cell antigen receptor beta polypeptide T cell receptor beta cluster antibody
    • T cell receptor alpha (V D J C) antibody
    • T cell receptor alpha chain C region antibody
    • T cell receptor alpha constant antibody
    • T cell receptor alpha locus antibody
    • T cell receptor beta cluster antibody
    • T cell receptor beta locus antibody
    • TCRA antibody
    • TCRB antibody
    • TCRD antibody
    • TRA antibody
    • TRAC antibody
    • TRB antibody
    see all

References

ab176542 has not yet been referenced specifically in any publications.

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