Key features and details
- Armenian Hamster monoclonal [UC7-13D5] to TCR gamma + TCR delta (Biotin)
- Suitable for: Functional Studies, Flow Cyt, IHC-Fr, IP
- Reacts with: Mouse
- Conjugation: Biotin
- Isotype: IgG
Product nameAnti-TCR gamma + TCR delta antibody [UC7-13D5] (Biotin)
See all TCR gamma + TCR delta primary antibodies
DescriptionArmenian Hamster monoclonal [UC7-13D5] to TCR gamma + TCR delta (Biotin)
Host speciesArmenian hamster
Specificityab25209 is specific for the gamma-delta heterodimer and plate-bound ab25209 activates gamma-delta TCR bearing cells. This antibody does not react with alpha-beta TCR-expressing T cells.
Tested applicationsSuitable for: Functional Studies, Flow Cyt, IHC-Fr, IPmore details
Species reactivityReacts with: Mouse
The details of the immunogen for this antibody are not available.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Concentration information loading...
Our Abpromise guarantee covers the use of ab25209 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||Use at an assay dependent dilution. In vitro activation of gamma-delta TCR-bearing cells and depletion of gamma-delta TCR-expressing cells.|
|Flow Cyt||Use 0.3µg for 106 cells.|
|IHC-Fr||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
RelevanceT cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one a and one b chain or one d and one g chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The g/d TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most g/d T cells are CD4-/CD8-, some are CD8+. T cells expressing the g/d TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease.
Cellular localizationType I membrane protein
- CD_antigen=CD3d antibody
- CD3D antibody
- CD3G antibody
ab25209 has been referenced in 1 publication.
- Dent AL et al. Self-reactive gamma delta T cells are eliminated in the thymus. Nature 343:714-9 (1990). PubMed: 1968227