Anti-TCR V beta 5 antibody [MEM-262] (ab1898)
Key features and details
- Mouse monoclonal [MEM-262] to TCR V beta 5
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-TCR V beta 5 antibody [MEM-262] -
Description
Mouse monoclonal [MEM-262] to TCR V beta 5 -
Host species
Mouse -
Specificity
The antibody recognizes beta chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells. This subset is larger than that recognized by other V(beta5.3)-specific antibodies. -
Species reactivity
Reacts with: Human -
Immunogen
Human thymoma cell line HPB-ALL.
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General notes
Functional Application Activates T cells (V beta 5-related subset).
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
Purified from hybridoma culture supernatant. Purity >95% by SDS-PAGE. -
Clonality
Monoclonal -
Clone number
MEM-262 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Relevance
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. The Vß5 TCR is a variant of the TCR ß chain. It belongs to Ig superfamily and is expressed by a subset of peripheral blood T cells and some T cell clones. TCR Vß5 has been reported to recognize some staphylococcus bacterial superantigens. -
Cellular localization
Cell Membrane -
Database links
- Entrez Gene: 28612 Human
- Omim: 186930 Human
- SwissProt: P03979 Human
- SwissProt: P04435 Human
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Alternative names
- T cell receptor antibody
- TCB antibody
- TCRB antibody
see all
Protocols
References (3)
ab1898 has been referenced in 3 publications.
- Wang CT et al. Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats. J Formos Med Assoc 114:328-38 (2015). PubMed: 25839766
- Grabherr MG et al. Exploiting nucleotide composition to engineer promoters. PLoS One 6:e20136 (2011). PubMed: 21625601
- Pavlistová D et al. A novel monoclonal reagent recognizing native and denatured Vbeta5.3-related chains of human T cell receptor. Immunol Lett 88:105-8 (2003). PubMed: 12880678