Overview

  • Product name

    TCS 359, FLT3 receptor tyrosine kinase inhibitor
  • Description

    Potent FLT3 receptor tyrosine kinase inhibitor
  • Biological description

    Potent FLT3 receptor tyrosine kinase inhibitor (IC50 = 42 nM). Selective over 22 other kinases. Shows antiproliferative effects (IC50 = 340 nM for Human acute myelocytic leukemia MV4-11 cells).
  • Purity

    > 99%
  • CAS Number

    301305-73-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
  • Molecular weight

    360.43
  • Molecular formula

    C18H20N2O4S
  • PubChem identifier

    1048845
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COc1ccc(cc1OC)C(=O)Nc3sc2CCCCc2c3C(N)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Patch RJ  et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett 16:3282-6 (2006). Read more (PubMed: 16580199) »

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