Overview

  • Product name

    Anti-TCTN1 antibody
  • Description

    Rabbit polyclonal to TCTN1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    15 amino acid synthetic peptide near the N-terminus of Human TCTN1 (NP_001076007).

  • Positive control

    • Mouse kidney tissue lysate, Human kidney tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab105381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 64 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
  • Sequence similarities

    Belongs to the tectonic family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • JBTS13 antibody
    • TCTN1 antibody
    • TECT1 antibody
    • TECT1_HUMAN antibody
    • Tectonic family member 1 antibody
    • Tectonic-1 antibody
    see all

Images

  • ab105381 at 5 µg/ml staining TCTN1 in Human kidney tissue by Immunohistochemistry
  • Lane 1 : Anti-TCTN1 antibody (ab105381) at 1 µg/ml
    Lane 2 : Anti-TCTN1 antibody (ab105381) at 2 µg/ml

    All lanes : Mouse kidney tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 64 kDa

  • Immunofluorescence of TCTN1 in Human Kidney cells using ab105381 at 20 ug/ml.

References

This product has been referenced in:

  • Liu W  et al. MiR-1256 suppresses proliferation and migration of non-small cell lung cancer via regulating TCTN1. Oncol Lett 16:1708-1714 (2018). Read more (PubMed: 30008857) »
  • Meng D  et al. Expression and prognostic significance of TCTN1 in human glioblastoma. J Transl Med 12:288 (2014). IHC ; Human . Read more (PubMed: 25304031) »
See all 2 Publications for this product

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