Anti-TDO2/TDO antibody (ab76859)
Key features and details
- Mouse polyclonal to TDO2/TDO
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TDO2/TDO antibody
See all TDO2/TDO primary antibodies -
Description
Mouse polyclonal to TDO2/TDO -
Host species
Mouse -
Tested applications
Suitable for: ELISA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein within Human TDO2/TDO. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_005642.1 -
Positive control
- TDO2/TDO transfected lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab76859 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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WB |
1/500 - 1/1000. Predicted molecular weight: 48 kDa.
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Notes |
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ELISA
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 48 kDa. |
Target
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Function
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. -
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. -
Sequence similarities
Belongs to the tryptophan 2,3-dioxygenase family. - Information by UniProt
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Database links
- Entrez Gene: 6999 Human
- Omim: 191070 Human
- SwissProt: P48775 Human
- Unigene: 183671 Human
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Alternative names
- 3-dioxygenase antibody
- T23O_HUMAN antibody
- TDO 2 antibody
see all
Images
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All lanes : Anti-TDO2/TDO antibody (ab76859) at 1/500 dilution
Lane 1 : TDO2/TDO transfected 293T cells lysate
Lane 2 : Non transfected 293T cells lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab76859 has been referenced in 1 publication.
- Perez-Pardo P et al. Pharmacological validation of TDO as a target for Parkinson's disease. FEBS J 288:4311-4331 (2021). PubMed: 33471408