Publishing research using ab4166? Please let us know so that we can cite the reference in this datasheet.

ab4166 has been referenced in 20 publications.

  • Meisenberg C  et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res 45:1159-1176 (2017). WB ; Human . PubMed: 28180300
  • Chiang SC  et al. Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Sci Adv 3:e1602506 (2017). PubMed: 28508041
  • Takiuchi Y  et al. HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia. Sci Rep 7:12849 (2017). PubMed: 28993637
  • Cuya SM  et al. Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin. Oncotarget 7:86660-86674 (2016). WB . PubMed: 27893431
  • Meisenberg C  et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res N/A:N/A (2016). WB ; Human . PubMed: 27789688
  • Tada K  et al. Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia. Sci Adv 1:e1400203 (2015). PubMed: 26601161
  • Meisenberg C  et al. Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Mol Cancer Ther 14:575-85 (2015). PubMed: 25522766
  • Meisenberg C  et al. TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. J Cancer Sci Ther 6:258-267 (2014). WB . PubMed: 25232464
  • Gao R  et al. Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel. DNA Repair (Amst) 13:1-9 (2014). WB . PubMed: 24355542
  • Das BB  et al. PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage. Nucleic Acids Res 42:4435-49 (2014). Human . PubMed: 24493735
  • Gómez-Herreros F  et al. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet 46:516-21 (2014). Human . PubMed: 24658003
  • Walker S  et al. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Anal Biochem 454:17-22 (2014). WB ; Human . PubMed: 24637157
  • Perego P  et al. Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition. Biochem Pharmacol 83:27-36 (2012). WB ; Human . PubMed: 21978643
  • Murai J  et al. Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells. J Biol Chem 287:12848-57 (2012). PubMed: 22375014
  • Hudson JJ  et al. SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. Nat Commun 3:733 (2012). WB . PubMed: 22415824
  • Gajewski S  et al. Analysis of the active-site mechanism of tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily. J Mol Biol 415:741-58 (2012). PubMed: 22155078
  • Das BB  et al. Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci U S A 107:19790-5 (2010). WB, ICC/IF ; Human . PubMed: 21041670
  • Das BB  et al. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J 28:3667-80 (2009). PubMed: 19851285
  • Leduc F  et al. DNA damage response during chromatin remodeling in elongating spermatids of mice. Biol Reprod 78:324-32 (2008). PubMed: 18032420
  • El-Khamisy SF  et al. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature 434:108-13 (2005). PubMed: 15744309


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