Overview

  • Product name

    Anti-TDRD1 antibody
  • Description

    Rabbit polyclonal to TDRD1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human TDRD1 (internal sequence). The exact sequence is proprietary.
    Database link: Q9BXT4

  • Positive control

    • WB: Human testis tissue extract. IHC-P: Human lung cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 132 kDa.

Target

  • Function

    Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
  • Tissue specificity

    Testis and ovary specific. Also expressed in several cancers.
  • Sequence similarities

    Belongs to the TDRD1 family.
    Contains 1 MYND-type zinc finger.
    Contains 4 Tudor domains.
  • Domain

    Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.
  • Cellular localization

    Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
  • Information by UniProt
  • Database links

  • Alternative names

    • Cancer/testis antigen 41.1 antibody
    • CT41.1 antibody
    • FLJ21082 antibody
    • MTR 1 antibody
    • TDRD 1 antibody
    • tdrd1 antibody
    • TDRD1_HUMAN antibody
    • Tudor domain containing 1 antibody
    • Tudor domain containing protein 1 antibody
    • Tudor domain-containing protein 1 antibody
    see all

Images

  • Anti-TDRD1 antibody (ab229621) at 1/1000 dilution + Human testis tissue extract at 30 µg

    Developed using the ECL technique.

    Predicted band size: 132 kDa



    7.5% SDS-PAGE

  • Paraffin-embedded human lung cancer tissue stained for TDRD1 with ab229621 at 1/500 dilution in immunohistochemical analysis.

References

ab229621 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229621.
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