Overview

  • Product name

    TDZD 8, GSK-3beta inhibitor
  • Description

    Selective, non-ATP competitive GSK-3β inhibitor
  • Biological description

    Selective, non-ATP competitive GSK-3β inhibitor (IC50 = 2 µM). Binds to the active site of GSK3β. Also inhibits PKC activity (IC50 values are 1.4, 1.1 and 5.5 µM at βI, δ and ι isoforms respectively). IC50 values are > 100 µM for Cdk-1/cyclin B, CK-II and PKA. Shows neuroprotective effects.
  • Purity

    > 98%
  • CAS Number

    327036-89-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
  • Molecular weight

    222.26
  • Molecular formula

    C10H10N2O2S
  • PubChem identifier

    4124851
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Collino M  et al. Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. Shock 30:299-307 (2008). Read more (PubMed: 18323734) »
  • Guzman ML  et al. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood 110:4436-44 (2007). Read more (PubMed: 17785584) »
  • Martinez A  et al. First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 45:1292-9 (2002). Read more (PubMed: 11881998) »

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