Key features and details
- Selective, non-ATP competitive GSK-3β inhibitor
- CAS Number: 327036-89-5
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameTDZD 8, GSK-3beta inhibitor
DescriptionSelective, non-ATP competitive GSK-3β inhibitor
Biological descriptionSelective, non-ATP competitive GSK-3β inhibitor (IC50 = 2 µM). Binds to the active site of GSK3β. Also inhibits PKC activity (IC50 values are 1.4, 1.1 and 5.5 µM at βI, δ and ι isoforms respectively). IC50 values are > 100 µM for Cdk-1/cyclin B, CK-II and PKA. Shows neuroprotective effects.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142372 has not yet been referenced specifically in any publications.