Product nameAnti-TEA domain family member 2/ETF antibody
See all TEA domain family member 2/ETF primary antibodies
DescriptionRabbit polyclonal to TEA domain family member 2/ETF
Tested applicationsSuitable for: WB, IHC-P, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human TEA domain family member 2/ETF conjugated to keyhole limpet haemocyanin.
Database link: Q15562
- WB: HEK-293, RAW264.7 and H9C2 whole cell lysate. IHC-P: Human breast cancer tissue. ICC/IF: HepG2 cells.
Storage bufferpH: 7.3
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol
Concentration information loading...
Our Abpromise guarantee covers the use of ab273017 in the following tested applications.
|WB||1/500 - 1/2000. Predicted molecular weight: 49 kDa.|
|IHC-P||1/50 - 1/200.|
|ICC/IF||1/100 - 1/500.|
FunctionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Sequence similaritiesContains 1 TEA DNA-binding domain.
- Information by UniProt
- Embryonic TEA domain containing factor antibody
- Etdf antibody
- ETEF 1 antibody
All lanes : Anti-TEA domain family member 2/ETF antibody (ab273017) at 1/500 dilution
Lane 1 : HEK-293 (Human epithelial cell line from embryonic kidney) whole cell lysate
Lane 2 : RAW264.7 (Mouse macrophage cell line transformed with Abelson murine leukemia virus) whole cell lysate
Lane 3 : H9C2 (Rat heart myoblast cell line) whole cell lysates
Predicted band size: 49 kDa
Formalin-fixed, paraffin-embedded human breast cancer tissue stained for TEA domain family member 2/ETF using ab273017 at 1/50 in immunohistochemical analysis.
HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for TEA domain family member 2/ETF using ab273017 at 1/50 dilution in ICC/IF.
ab273017 has not yet been referenced specifically in any publications.