Product nameAnti-TEAD4 antibody - ChIP Grade
See all TEAD4 primary antibodies
DescriptionMouse monoclonal to TEAD4 - ChIP Grade
Tested applicationsSuitable for: WB, ChIP, CHIPseq, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat, Human, Recombinant fragment
Recombinant fragment, corresponding to amino acids 151-261 of Human TEAD4
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: None
PBS, pH 7.2
Concentration information loading...
PurityProtein G purified
Light chain typekappa
- Epigenetics and Nuclear Signaling
- Polymerase associated factors
- Pol II Transcription
ChIP Related Products
Our Abpromise guarantee covers the use of ab58310 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.|
|ChIP||Use at an assay dependent concentration. PubMed: 22529382|
|CHIPseq||Use at an assay dependent concentration. PubMed: 22529382|
|ICC/IF||Use at an assay dependent concentration. PubMed: 22529382|
FunctionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Tissue specificityPreferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Sequence similaritiesContains 1 TEA DNA-binding domain.
- Information by UniProt
- EFTR 2 antibody
- EFTR2 antibody
- hRTEF 1B antibody
This product has been referenced in:
- Maglic D et al. YAP-TEAD signaling promotes basal cell carcinoma development via a c-JUN/AP1 axis. EMBO J 37:N/A (2018). Read more (PubMed: 30037824) »
- Sakurai N et al. Effects of downregulating TEAD4 transcripts by RNA interference on early development of bovine embryos. J Reprod Dev 63:135-142 (2017). ICC/IF ; Cow . Read more (PubMed: 27941302) »