Overview

  • Product name

    Tegafur
  • Description

    Prodrug, metabolized to 5-fluorouracil
  • Biological description

    Prodrug, metabolized to 5-fluorouracil. Antimetabolite and antineoplastic agent. Orally active. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    17902-23-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione
  • Molecular weight

    200.17
  • Molecular formula

    C8H9FN2O3
  • PubChem identifier

    5386
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in hot water, in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(OC1)N2C=C(C(=O)NC2=O)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ozawa S  et al. Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver. Cancer Chemother Pharmacol 50:454-8 (2002). Read more (PubMed: 12451471) »
  • Ikeda K  et al. Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro. Clin Cancer Res 6:4409-15 (2000). Read more (PubMed: 11106261) »
  • Harada M  et al. Metabolism of tegafur in rat liver observed by in vivo 19F magnetic resonance spectroscopy and chromatography. Jpn J Cancer Res 83:387-91 (1992). Read more (PubMed: 1506273) »

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