Anti-Telethonin antibody (ab121868)
Key features and details
- Rabbit polyclonal to Telethonin
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Telethonin antibody
See all Telethonin primary antibodies -
Description
Rabbit polyclonal to Telethonin -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: CEVSEENCER REAFWAEWKD LTLSTRPEEG CSLHEEDTQR HETYHQQGQC QVLVQRSPWL MMRMGILGRG LPEYQ, corresponding to internal sequence amino acids 8-82 of Human Telethonin.
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Positive control
- IHC: Human heart muscle and skeletal muscle tissue. WB: Skeletal muscle tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121868 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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WB |
Use a concentration of 0.04 - 0.4 µg/ml.
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Notes |
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IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
Use a concentration of 0.04 - 0.4 µg/ml. |
Target
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Function
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk. -
Tissue specificity
Heart and skeletal muscle. -
Involvement in disease
Defects in TCAP are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TCAP are a cause of limb-girdle muscular dystrophy type 2G (LGMD2G) [MIM:601954]. LGMD2G is an autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
Defects in TCAP are the cause of cardiomyopathy dilated type 1N (CMD1N) [MIM:607487]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. -
Cellular localization
Cytoplasm > myofibril > sarcomere. - Information by UniProt
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Database links
- Entrez Gene: 8557 Human
- Omim: 604488 Human
- SwissProt: O15273 Human
- Unigene: 77628 Human
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Alternative names
- 19 kDa sarcomeric protein antibody
- CMD1N antibody
- CMH25 antibody
see all
Images
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Anti-Telethonin antibody (ab121868) at 0.4 µg/ml + Human skeletal muscle tissue
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Paraffin-embedded human skeletal muscle tissue stained for Telethonin using ab121868 at 1/50 dilution in immunohistochemical analysis
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Paraffin-embedded human heart tissue stained for Telethonin using ab121868 at 1/50 dilution in immunohistochemical analysis
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab121868 has been referenced in 1 publication.
- Brusa R et al. A new case of limb girdle muscular dystrophy 2G in a Greek patient, founder effect and review of the literature. Neuromuscul Disord 28:532-537 (2018). PubMed: 29759638