• Product name

  • Description

    Rabbit polyclonal to Telethonin
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    antigen sequence: CEVSEENCER REAFWAEWKD LTLSTRPEEG CSLHEEDTQR HETYHQQGQC QVLVQRSPWL MMRMGILGRG LPEYQ, corresponding to internal sequence amino acids 8-82 of Human Telethonin.

  • Positive control

    • Human heart muscle tissue; Telethonin transfected HEK293T cells.


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab121868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.


  • Function

    Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
  • Tissue specificity

    Heart and skeletal muscle.
  • Involvement in disease

    Defects in TCAP are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TCAP are a cause of limb-girdle muscular dystrophy type 2G (LGMD2G) [MIM:601954]. LGMD2G is an autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
    Defects in TCAP are the cause of cardiomyopathy dilated type 1N (CMD1N) [MIM:607487]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Cellular localization

    Cytoplasm > myofibril > sarcomere.
  • Information by UniProt
  • Database links

  • Alternative names

    • 19 kDa sarcomeric protein antibody
    • CMD1N antibody
    • CMH25 antibody
    • LGMD2G antibody
    • Limb girdle muscular dystrophy 2G (autosomal recessive) antibody
    • T-cap antibody
    • Tcap antibody
    • TELE antibody
    • Telethonin antibody
    • TELT_HUMAN antibody
    • Titin cap protein antibody
    • Titin-cap antibody
    see all


  • ab121868, at 1/45 dilution, staining Telethonin in paraffin-embedded Human heart muscle tissue by Immunohistochemistry.
  • All lanes : Anti-Telethonin antibody (ab121868) at 1/250 dilution

    Lane 1 : Vector only transfected HEK293T lysate
    Lane 2 : Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells

    Developed using the ECL technique.
  • Immunohistochemical staining of Human heart muscle shows distinct cytoplasmic positivity using ab121868


This product has been referenced in:

  • Brusa R  et al. A new case of limb girdle muscular dystrophy 2G in a Greek patient, founder effect and review of the literature. Neuromuscul Disord 28:532-537 (2018). Read more (PubMed: 29759638) »
See 1 Publication for this product

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