Product nameAnti-Telethonin antibody
See all Telethonin primary antibodies
DescriptionRabbit polyclonal to Telethonin
Tested applicationsSuitable for: WB, IHC-P, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat, Human
Recombinant full length protein corresponding to Human Telethonin.
Database link: O15273
- Mouse heart and skeletal muscle lysates; Rat heart and skeletal muscle lysates; HeLa cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab210773 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 19 kDa.|
|IHC-P||1/50 - 1/200.|
|ICC/IF||1/10 - 1/100.|
FunctionMuscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Tissue specificityHeart and skeletal muscle.
Involvement in diseaseDefects in TCAP are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TCAP are a cause of limb-girdle muscular dystrophy type 2G (LGMD2G) [MIM:601954]. LGMD2G is an autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
Defects in TCAP are the cause of cardiomyopathy dilated type 1N (CMD1N) [MIM:607487]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cellular localizationCytoplasm > myofibril > sarcomere.
- Information by UniProt
- 19 kDa sarcomeric protein antibody
- CMD1N antibody
- CMH25 antibody
All lanes : Anti-Telethonin antibody (ab210773) at 1/500 dilution
Lane 1 : Mouse heart extract
Lane 2 : Mouse skeletal muscle extract
Lane 3 : Rat heart extract
Lanes 4-5 : Rat skeletal muscle extract
Predicted band size: 19 kDa
Immunofluorescent analysis of HeLa cells labeling Telethonin with ab210773 at 1/10 dilution (red). Blue: DAPI for nuclear staining.
ab210773 has not yet been referenced specifically in any publications.