• Product name

  • Description

    Rabbit polyclonal to TEM8/ATR
  • Host species

  • Specificity

    This antibody will recognize only the largest isoform of TEM8/ATR.

  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human TEM8/ATR (C terminal).

  • Positive control

    • K562 cell lysates.
  • General notes

     This product was previously labelled as TEM8




Our Abpromise guarantee covers the use of ab21269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.


  • Function

    Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • Tissue specificity

    Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • Involvement in disease

    Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • Sequence similarities

    Belongs to the ATR family.
    Contains 1 VWFA domain.
  • Domain

    Binding to PA occurs through the VWA domain.
  • Cellular localization

    Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • Database links

  • Alternative names

    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all


  • Lane 1 : Anti-TEM8/ATR antibody (ab21269) at 0.5 µg/ml
    Lane 2 : Anti-TEM8/ATR antibody (ab21269) at 1 µg/ml
    Lane 3 : Anti-TEM8/ATR antibody (ab21269) at 2 µg/ml

    All lanes : K562 cell lysate

    Predicted band size: 63 kDa

    Western blot analysis of TEM8/ATR in K562 cell lysates with ab21269 at (A) 0.5, (B) 1 and (C) 2µg/ml.

  • ab21269 at 2µg/ml staining TEM8/ATR in K562 cells by ICC/IF


This product has been referenced in:

  • Hu K  et al. Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts. Matrix Biol 62:105-114 (2017). Read more (PubMed: 28011198) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for contacting us.

To our knowledge, neither of these antibodies have been used in any references yet. All of the known references for our products can be found on the Specific References tab of the online datasheet. Please let me know if you need any additional information or assistance.

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Thank you for contacting us.

The attached ICC/IF protocol was used to validate ab129004 but would also be suitable for use with ab21269. The recommended dilutions for these antibodies are 1:250 - 500. I hope this helps, please let me know if you need any additional information or assistance.

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