Overview

  • Product name

    Temocapril hydrochloride, ACE inhibitor
  • Description

    ACE inhibitor
  • Biological description

    ACE (angiotensin converting enzyme) inhibitor. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    110221-44-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[6-[(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid hydrochloride
  • Molecular weight

    513.07
  • Molecular formula

    C23H28N2O5S2.HCl
  • PubChem identifier

    9827796
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(C2=O)CC(=O)O)C3=CC=CS3.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nozawa T & Imai T Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity. Drug Metab Dispos 39:1263-9 (2011). Read more (PubMed: 21474683) »
  • Kaihara M  et al. Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats. Acta Med Okayama 63:35-42 (2009). Read more (PubMed: 19247421) »
  • Yasunari K  et al. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev 22:189-98 (2004). Read more (PubMed: 15492767) »

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