Overview

  • Product name

    Anti-Tensin 3 antibody
  • Description

    Rabbit polyclonal to Tensin 3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Tensin 3 (internal sequence).
    Database link: Q68CZ2

  • Positive control

    • Human heart tissue; COS7 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab178554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/500.
IHC-P 1/50 - 1/100.

Target

  • Function

    May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.
  • Tissue specificity

    Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
  • Sequence similarities

    Contains 1 C2 tensin-type domain.
    Contains 1 phosphatase tensin-type domain.
    Contains 1 SH2 domain.
  • Post-translational
    modifications

    EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.
  • Cellular localization

    Cell junction, focal adhesion.
  • Information by UniProt
  • Database links

  • Alternative names

    • TEM 6 antibody
    • TEM6 antibody
    • TENS 1 antibody
    • TENS 3 antibody
    • TENS1 antibody
    • TENS3 antibody
    • TENS3_HUMAN antibody
    • Tensin-3 antibody
    • tensin-like SH2 domain containing 1 antibody
    • Tensin-like SH2 domain containing protein 1 antibody
    • Tensin-like SH2 domain- containing protein 1 antibody
    • Tensin-like SH2 domain-containing protein 1 antibody
    • thyroid specific PTB domain protein antibody
    • TNS 3 antibody
    • TNS3 antibody
    • TPP antibody
    • Tumor endothelial marker 6 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human heart tissue labeling Tensin 3 with ab178554 at 1/50 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

  • Immunofluorescent analysis of COS7 cells labeling Tensin 3 with ab178554 at 1/100 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

References

ab178554 has not yet been referenced specifically in any publications.

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