Key features and details
- Rabbit polyclonal to Tensin 3
- Suitable for: ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Tensin 3 antibody
DescriptionRabbit polyclonal to Tensin 3
Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Tensin 3 (internal sequence).
Database link: Q68CZ2
- Human heart tissue; COS7 cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
PBS without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab178554 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/100 - 1/500.|
|IHC-P||1/50 - 1/100.|
FunctionMay play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.
Tissue specificityExpressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
Sequence similaritiesContains 1 C2 tensin-type domain.
Contains 1 phosphatase tensin-type domain.
Contains 1 SH2 domain.
modificationsEGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.
Cellular localizationCell junction, focal adhesion.
- Information by UniProt
- TEM 6 antibody
- TEM6 antibody
- TENS 1 antibody
Immunohistochemical analysis of paraffin-embedded Human heart tissue labeling Tensin 3 with ab178554 at 1/50 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.
Immunofluorescent analysis of COS7 cells labeling Tensin 3 with ab178554 at 1/100 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.
ab178554 has not yet been referenced specifically in any publications.