Teprenone (Geranylgeranylacetone), HSP70, HSPB8, and HSPB1 expression inducer (ab146190)

Overview

  • Product name

    Teprenone (Geranylgeranylacetone), HSP70, HSPB8, and HSPB1 expression inducer
  • Description

    HSP70, HSPB8, and HSPB1 expression inducer
  • Alternative names

    • Geranylgeranylacetone
  • Biological description

    HSP70, HSPB8, and HSPB1 expression inducer. Induces Trx-1 expression and NF-kB nuclear translocation. Activates thioredoxin reductase. Shows hepatoprotective, anti-ischemic and antiulcerative effects in vivo. Orally active.
  • CAS Number

    6809-52-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5E,9E,13E)-6,10,14,18-Tetramethylnonadeca-5,9,13,17-tetraen-2-one

  • Molecular weight

    330.55
  • Molecular formula

    C23H38O
  • PubChem identifier

    5282199
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO (up to 30mg/mL).

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CCC(=O)C)/C)/C)/C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cao W  et al. Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved. Pulm Pharmacol Ther 32:109-15 (2015). Read more (PubMed: 25748490) »
  • He W  et al. Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70. Mol Med Rep : (2015). Read more (PubMed: 26165998) »
  • Kobayashi T  et al. Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. Pharmacol Res 43:23-30 (2001). Read more (PubMed: 11207062) »

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