Terazosin hydrochloride dihydrate, Adrenergic alpha-receptor antagonist (ab142601)

Overview

  • Product name

    Terazosin hydrochloride dihydrate, Adrenergic alpha-receptor antagonist
  • Description

    Adrenergic α-receptor antagonist
  • Biological description

    Adrenergic α-receptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Tube formation and proliferation inhibitor in tumor cells (IC50 = 6.8 and 9.9 μM, respectively). Antiangiogenic and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    70024-40-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mustafa S  et al. Identification and profiling of novel a1A-adrenoceptor-CXC chemokine receptor 2 heteromer. J Biol Chem 287:12952-65 (2012). Read more (PubMed: 22371491) »
  • Pan SL  et al. Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells. J Urol 169:724-9 (2003). Read more (PubMed: 12544352) »
  • Kyncl JJ Pharmacology of terazosin: an alpha 1-selective blocker. J Clin Pharmacol 33:878-83 (1993). Read more (PubMed: 7901242) »

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