Overview

  • Product name

    Terpendole E, ACAT and Eg5 inhibitor
  • Description

    ACAT and Eg5 inhibitor
  • Biological description

    ACAT and Eg5 inhibitor. Selectively inhibits M phase in the cell cycle. Terpendole C (ab144367) analog. Partially inhibits Eg5-microtubule interaction. Inhibits both motor and microtubule-stimulated ATPase activities of Eg5.
  • Purity

    > 95%
  • CAS Number

    167427-23-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    437.61
  • Molecular formula

    C28H39NO3
  • PubChem identifier

    10094631
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@]12CC[C@H]3[C@]([C@@H]1CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)([C@@H](C[C@H](O3)C(C)(C)O)O)C
  • Source

    Albophoma yamanashiensis

  • Research areas

References

This product has been referenced in:

  • Tarui Y  et al. Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5. Chembiochem 15:934-8 (2014). Read more (PubMed: 24648249) »
  • Motoyama T  et al. Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. Chem Biol 19:1611-9 (2012). Read more (PubMed: 23261604) »
  • Nakazawa J  et al. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. Chem Biol 10:131-7 (2003). Read more (PubMed: 12618185) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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