Tertiapin Q, blocker of inward-rectifier r K+ channels (ab120432)

Overview

  • Product name

    Tertiapin Q, blocker of inward-rectifier r K+ channels
  • Description

    Potent inward rectifier K+ channel blocker
  • Biological description

    Potent blocker of inward rectifier K+ channels. Stable analog of the bee venom tertiapin. High affinity for ROMK1 and GIRK1/4 (Ki values are 1.3 and 13.3 nM, respectively). Displays >250-fold selectivity over many other Kir subtypes.
  • Purity

    > 95%
  • General notes

    Sold under license granted by the University of Pennsylvania.
  • CAS Number

    252198-49-5
  • Chemical structure

    Chemical Structure

Properties

Images

  • Tertiapin Q, blocker of inward-rectifier r K+ channels

References

This product has been referenced in:

  • Ramu Y  et al. Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc Natl Acad Sci U S A 105:10774-8 (2008). Read more (PubMed: 18669667) »
  • Kanjhan R  et al. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. J Pharmacol Exp Ther 314:1353-61 (2005). Read more (PubMed: 15947038) »
  • Jin W  et al. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry 38:14294-301 (1999). Read more (PubMed: 10572004) »
See all 5 Publications for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

Thank you for contacting Abcam.

We currently run our HPLC at 25°C and we do not believe that this should cause issue with the compound. Although we do not have experience with preparing samples in phosphate buffer, as this seems to be the main difference between our preparation and yours it may be possible that this has caused issue with the HPLC trace.
Please do not hesitate to contact me should you have any further questions.

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Answer

Thank you for contacting Abcam.

I have been in contact with the lab about the issue you were having with ab120432, Tertiapin Q. Please see their response below:

Following your question, Tertiapin Q has been re-submitted for quality control (QC) and has passed this. Please find attached the HPLC trace for this. In this trace there was one peak observed. We believe that you may be seeing two peaks due to partial ionisation at the pH of your buffer. Is it possible to modify your HPLC conditions to match our analysis? This may prevent the two peaks that you have previously seen.

Please let me know if there is anything else I can help you with.

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