Anti-Tetanus Toxin antibody (ab53829)
Key features and details
- Rabbit polyclonal to Tetanus Toxin
- Suitable for: WB, ELISA
- Isotype: IgG
Overview
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Product name
Anti-Tetanus Toxin antibody
See all Tetanus Toxin primary antibodies -
Description
Rabbit polyclonal to Tetanus Toxin -
Host species
Rabbit -
Tested applications
Suitable for: WB, ELISAmore details -
Species reactivity
Reacts with: Clostridium tetani -
Immunogen
Tissue, cells or virus corresponding to Tetanus Toxin. Tetanus toxoid (formaldehyde inactivated tetanus toxin).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.098% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53829 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent dilution. Predicted molecular weight: 150 kDa.
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ELISA |
Use at an assay dependent dilution.
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Notes |
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WB
Use at an assay dependent dilution. Predicted molecular weight: 150 kDa. |
ELISA
Use at an assay dependent dilution. |
Target
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Relevance
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation. -
Cellular localization
Secreted -
Alternative names
- Tentoxylysin antibody
- Tetanus toxin chain H antibody
- Tetanus toxin chain L antibody
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Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab53829 has been referenced in 2 publications.
- Chai P et al. The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197. Appl Microbiol Biotechnol 105:1683-1692 (2021). PubMed: 33511443
- Mittal AM et al. Multiple network properties overcome random connectivity to enable stereotypic sensory responses. Nat Commun 11:1023 (2020). PubMed: 32094345